The information contained on this site is general in nature, and should not be used in replacement of your facility policy manual.
Cleaning Your Barrier Isolator
Outside the Isolator
The outside of the isolator can be cleaned at any time while the unit is closed and the procedure does not require personnel in addition to that normally used when operating the isolator. The stainless steel should be cleaned using Pharma-Hol™ sterile 70% IPA or a solution specifically designed for cleaning stainless steel. The acrylic front and side panels should be cleaned with a Pharma-Wipe™ wiper and mild detergent, or a solution specifically designated for the cleaning of acrylic surfaces.
Never use abrasive cleaners or organic solvents on acrylic components. Work from top to bottom. Do not remove or spray the pre-filter at the top of the unit. When cleaning the airlock HEPA filter housings, do not directly spray; instead spray a cleaning agent like Pharma-Hol™ onto the Pharma-Wipe™ and wipe the outside surface off.
NEVER spray cleaner of any type directly at the control panel located above the airlock. Always spray onto a clean Pharma-Wipe™ wiper and wipe the surface, switches and knobs.
Inside the Airlock
Open the outer airlock door. Spray a clean Pharma-Wipe™ with Pharma-Hol™ and wipe the top HEPA filter protector from front to back moving left to right with overlapping strokes.
Spray the Pharma-Wipe™ wiper with Pharma-Hol™ cleaner and wipe the back HEPA filter protector from top to bottom, moving left to right with overlapping strokes.
Spray cleaner on the inside of the outer airlock door and remaining side and wipe with a Pharma-Wipe™ wiper from top to bottom moving left to right with overlapping strokes.
Open the airlock door into the work area and slide the tray out into the work area. Spray the floor of the airlock chamber with cleaner and wipe down with a Pharma-Wipe™.
Spray the tray with cleaner and wipe with a Pharma-Wipe™ wiper from left to right and from front to back with overlapping strokes. Slide the tray back into the airlock.
Spray the inside of the inner airlock door and wipe with a Pharma-Wipe™ from top to bottom moving left to right with overlapping strokes. Close and latch the inner airlock door.
Repeat steps above using sterile water to rinse any disinfectant cleaner away.
Repeat the steps above using Pharma-Hol™ to sterilize the surfaces and run a purge cycle.
Inside the Isolator
A water-based, high pH disinfectant cleaner should be used, followed by Pharma-Hol™ sterile 70% IPA. It is recommended that you clean the airlock prior to the work area.
Spray high pH disinfectant cleaner on a Pharma-Wipe™ lint-free wiper. Wipe the filter diffuser in the top of the work area wiping from side to side, overlapping strokes. Work outward from back to front.
Spray the back wall of the work area. Wipe the wall beginning at the top and wipe from top to bottom using overlapping strokes, working downward toward the work surface and wipe the rear air return grill. Work sideways left to right.
Spray the sides of the work area. Using overlapping strokes, wipe from top to bottom working downward toward the work surface. Be sure to clean the entire airlock door surface that is exposed to the inside of the work area, including the handle.
Slide the left tray over the right tray; spray the interior bottom of the isolator. Clean by wiping from the front to the back using overlapping strokes working from front to back. Be sure to clean the sides and back under the sliding work tray and air return grill.
Slide both work trays to the left and repeat the procedure from above. Sliding work trays can be removed for cleaning if you prefer.
Spray the sliding work tray and wipe using a side to side motion, using overlapping strokes working from back to front, and clean all inside and outside edges.
Slide the clean tray to the side and repeat this procedure on the other tray.
Remove glove sleeves and spray the inside of the open front access window with Pharma-Hol™, or use a Pharma-Sat™ pre-saturated 70% IPA wiper. Clean from top to bottom using overlapping strokes.
Spray a clean Pharma-Wipe™ wiper with Pharma-Hol™ and use it to clean glove ports.
Spray a clean Pharma-Wipe™ wiper with Pharma-Hol™ and use it to clean IV hanging bar and hooks.
Spray a clean Pharma-Wipe™ wiper with Pharma-Hol™ and wipe the front air return grill.
Close the front window. Clean the glove sleeves and gloves and replace on the front window.
Open the front window and repeat the previous steps, without removing the sleeves and gloves, with sterile water to rinse away any disinfectant.
Turn on the barrier isolator unit. Close the front access window.
Spray Pharma-Hol™ sterile 70% IPA on all surfaces of the rest of the work area, under sliding trays, the inside of the front access window, gloves and sleeves.
Cleaning the Barrier Isolator between CSPs – Compound Sterile Preparations
Open only the outer door of the airlock. Spray a Pharma-Wipe™ wiper with Pharma-Hol™ sterile 70% IPA or use a Pharma-Sat™ pre-saturated 70% IPA wiper to wipe the top and back HEPA filter covers.
Spray the remaining surfaces, including the trays, with Pharm-Hol™ and wipe with overlapping strokes.
Leave the spray bottle in the airlock and close the outer airlock door. Run a purge cycle.
Open the inner airlock door and remove the spray bottle.
Spray all vertical surfaces with Pharma-Hol™ and wipe from top to bottom with clean Pharma-Wipe™ wipers, overlapping strokes moving left to right.
Spray the air grills and work surface with Pharma-Hol™ and wipe from left to right with overlapping strokes, moving back to front.
Spray the sleeves and gloves and rub together, then wipe off.
Spray the same surfaces lightly and allow to air dry.
Wipe down all vials and other compounding materials with Pharma-Hol™ before placing them in the airlock.